[HTML][HTML] Parathyroid hormone stimulates receptor activator of NFκB ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response …
Parathyroid hormone (PTH) stimulates osteoclast formation by binding to its receptor on
stromal/osteoblastic cells and stimulating the production of receptor activator of NFκB ligand
(RANKL) and inhibiting the expression of osteoprotegerin (OPG). However, the mechanisms
through which PTH regulates these genes remain unknown. Here we report that PTH
stimulated RANKL gene transcription and increased RANKL mRNA stability in murine
stromal/osteoblastic cells stably expressing human PTH/PTH-related protein receptor 1. PTH …
stromal/osteoblastic cells and stimulating the production of receptor activator of NFκB ligand
(RANKL) and inhibiting the expression of osteoprotegerin (OPG). However, the mechanisms
through which PTH regulates these genes remain unknown. Here we report that PTH
stimulated RANKL gene transcription and increased RANKL mRNA stability in murine
stromal/osteoblastic cells stably expressing human PTH/PTH-related protein receptor 1. PTH …
