[PDF][PDF] Characterization of [18F] fluoroetanidazole, a new radiopharmaceutical for detecting tumor hypoxia
JS Rasey, PD Hofstrand, LK Chin… - Journal of Nuclear …, 1999 - Soc Nuclear Med
JS Rasey, PD Hofstrand, LK Chin, TJ Tewson
Journal of Nuclear Medicine, 1999•Soc Nuclear MedCharacterization of [ @ 8F]Fluoroetanidazole, Tumor Hypoxia Page 1 reduced tumor
oxygenation and poor response to radiation treatment (1,2), and these early observations
have been confirmed and extended by modem studies. Low levels of tumor oxygenation,
measured with polarographic oxygen electrodes and typically defined as the proportion of
oxygen partial pressures at or below the range of 2.5—10mm Hg, show a strong correlation
with poor outcomes in head and neck cancer and cervical carcinoma treated with radiation …
oxygenation and poor response to radiation treatment (1,2), and these early observations
have been confirmed and extended by modem studies. Low levels of tumor oxygenation,
measured with polarographic oxygen electrodes and typically defined as the proportion of
oxygen partial pressures at or below the range of 2.5—10mm Hg, show a strong correlation
with poor outcomes in head and neck cancer and cervical carcinoma treated with radiation …
The methods for synthesis of [18F} FETAwere reported by Tewson (11).[†8F] FMISOwas synthesizedas describedby Grier son etal.(7).
Society of Nuclear Medicine and Molecular Imaging