X-linked hypophosphatemia (XLH) is an X-linked dominant disorder that is characterized by
rachitic bone disease and hypophosphatemia due to renal phosphate transport defect. The
candidate gene for XLH, PHEX, has recently been identified and found to share high
homology with endopeptidases. PHEX is expressed in various tissues, including bones, and
the available evidence today indicates that bones can release abnormal humoral factors that
affect bone mineralization and proximal tubule phosphate transport in XLH. It was, therefore …