Molecular Determinants of Listeria monocytogenes Virulence

O Dussurget, J Pizarro-Cerda, P Cossart - Annu. Rev. Microbiol., 2004 - annualreviews.org
Annu. Rev. Microbiol., 2004annualreviews.org
▪ Abstract Listeria monocytogenes is the etiological agent of listeriosis, a severe human
foodborne infection characterized by gastroenteritis, meningitis, encephalitis, abortions, and
perinatal infections. This gram-positive bacterium is a facultative intracellular pathogen that
induces its own uptake into nonphagocytic cells and spreads from cell to cell using an actin-
based motility process. This review covers both well-established and recent advances in the
characterization of L. monocytogenes virulence determinants and their role in the …
▪ Abstract 
Listeria monocytogenes is the etiological agent of listeriosis, a severe human foodborne infection characterized by gastroenteritis, meningitis, encephalitis, abortions, and perinatal infections. This gram-positive bacterium is a facultative intracellular pathogen that induces its own uptake into nonphagocytic cells and spreads from cell to cell using an actin-based motility process. This review covers both well-established and recent advances in the characterization of L. monocytogenes virulence determinants and their role in the pathophysiology of listeriosis.
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