The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
A Ben‐Nun, H Wekerle… - European journal of …, 1981 - Wiley Online Library
A Ben‐Nun, H Wekerle, IR Cohen
European journal of immunology, 1981•Wiley Online LibraryThe isolation and propagation of functional antigen‐specific lines of T lymphoblasts is
described. These lines were found to recognize foreign or self antigens in association with
accessory cells of syngeneic major histocompatibility complex genotype. Intravenous
inoculation of a T cell reactive only against myelin basic protein led to development of
clinical paralysis in syngeneic rats. Thus, it is possible to study biological function as well as
antigen specificity using T cell lines.
described. These lines were found to recognize foreign or self antigens in association with
accessory cells of syngeneic major histocompatibility complex genotype. Intravenous
inoculation of a T cell reactive only against myelin basic protein led to development of
clinical paralysis in syngeneic rats. Thus, it is possible to study biological function as well as
antigen specificity using T cell lines.
Abstract
The isolation and propagation of functional antigen‐specific lines of T lymphoblasts is described. These lines were found to recognize foreign or self antigens in association with accessory cells of syngeneic major histocompatibility complex genotype. Intravenous inoculation of a T cell reactive only against myelin basic protein led to development of clinical paralysis in syngeneic rats. Thus, it is possible to study biological function as well as antigen specificity using T cell lines.
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