IL-12/IL-12R system in multiple sclerosis
V Özenci, M Pashenkov, M Kouwenhoven… - Journal of …, 2001 - Elsevier
IL-12/IL-12 receptor (IL-12R) system orchestrates the Th1 pathway of the immune system by
maintaining one of the major bridges between innate and adaptive immune responses.
Here, we studied both sides of this system in patients with multiple sclerosis (MS) and in
controls. MS patients displayed elevated IL-12Rβ1 and IL-12Rβ2 expression on PHA-
activated T cells compared to healthy subjects. Higher percentages of IL-12Rβ1 and IL-
12Rβ2 positive T cells in cerebrospinal fluid (CSF) compared to blood were observed both …
maintaining one of the major bridges between innate and adaptive immune responses.
Here, we studied both sides of this system in patients with multiple sclerosis (MS) and in
controls. MS patients displayed elevated IL-12Rβ1 and IL-12Rβ2 expression on PHA-
activated T cells compared to healthy subjects. Higher percentages of IL-12Rβ1 and IL-
12Rβ2 positive T cells in cerebrospinal fluid (CSF) compared to blood were observed both …