Laminin-5 (previously known as kalinin, epiligrin, and nicein) is an adhesive protein
localized to the anchoring filaments within the lamina lucida space of the basement
membrane zone lying between the epidermis and dermis of human skin. Anchoring
filaments are structures within the lamina lucida and lie immediately beneath the
hemidesmosomes of the overlying basal keratinocytes apposed to the basement membrane
zone. Human keratinocytes synthesize and deposit laminin-5. Laminin-5 is present at the …

BACKGROUND Reepithelialization is an important component of wound healing. In the first
48 hours keratinocyte migration and proliferation are important events in this process.
Although the literature agrees that the risk/benefit of antiseptics has not been established,
hydrogen peroxide is still commonly used in the management of acute and chronic wounds.
OBJECTIVE The purpose of this study was to evaluate the effect of hydrogen peroxide on
human keratinocyte migration and proliferative potential. METHODS The viability and …