Normal and abnormal mechanisms of gene splicing and relevance to inherited skin diseases

V Wessagowit, VK Nalla, PK Rogan… - Journal of dermatological …, 2005 - Elsevier
The process of excising introns from pre-mRNA complexes is directed by specific genomic
DNA sequences at intron–exon borders known as splice sites. These regions contain well-
conserved motifs which allow the splicing process to proceed in a regulated and structured
manner. However, as well as conventional splicing, several genes have the inherent
capacity to undergo alternative splicing, thus allowing synthesis of multiple gene transcripts,
perhaps with different functional properties. Within the human genome, therefore, through …