Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels
G Zatti, A Burgo, M Giacomello, L Barbiero, R Ghidoni… - Cell calcium, 2006 - Elsevier
Presenilin-1 and-2 (PS1 and PS2) mutations, the major cause of familial Alzheimer's
disease (FAD), have been causally implicated in the pathogenesis of neuronal cell death
through a perturbation of cellular Ca2+ homeostasis. We have recently shown that, at
variance with previous suggestions obtained in cells expressing other FAD-linked PS
mutations, PS2-M239I and PS2-T122R cause a reduction and not an increase in cytosolic
Ca2+ rises induced by Ca2+ release from stores. In this contribution we have used different …
disease (FAD), have been causally implicated in the pathogenesis of neuronal cell death
through a perturbation of cellular Ca2+ homeostasis. We have recently shown that, at
variance with previous suggestions obtained in cells expressing other FAD-linked PS
mutations, PS2-M239I and PS2-T122R cause a reduction and not an increase in cytosolic
Ca2+ rises induced by Ca2+ release from stores. In this contribution we have used different …
