Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV
SP Galuska, I Oltmann-Norden, H Geyer… - Journal of biological …, 2006 - ASBMB
The post-translational modification of the neural cell adhesion molecule (NCAM) by
polysialic acid (polySia) represents a remarkable example of dynamic modulation of homo-
and heterophilic cell interactions by glycosylation. The synthesis of this unique carbohydrate
polymer depends on the polysialyltransferases ST8SiaII and ST8SiaIV. Aiming to
understand in more detail the contributions of ST8SiaII and ST8SiaIV to polySia biosynthesis
in vivo, we used mutant mouse lines that differ in the number of functional …
polysialic acid (polySia) represents a remarkable example of dynamic modulation of homo-
and heterophilic cell interactions by glycosylation. The synthesis of this unique carbohydrate
polymer depends on the polysialyltransferases ST8SiaII and ST8SiaIV. Aiming to
understand in more detail the contributions of ST8SiaII and ST8SiaIV to polySia biosynthesis
in vivo, we used mutant mouse lines that differ in the number of functional …
