[HTML][HTML] Attenuated Cerulein-Induced Pancreatitis in Nuclear Factor–κB–Deficient Mice
D Altavilla, C Famulari, M Passaniti, M Galeano… - Laboratory …, 2003 - Elsevier
Nuclear factor (NF)-κB plays a central role in acute pancreatitis. We studied cerulein (CER)-
induced pancreatitis in NF-κB knockout (KO) mice. NF-κB KO mice and normal control
littermate wild-type (WT) mice were given four hyperstimulating doses of cerulein every hour
to elicit secreatagogue-induced pancreatitis. Malonildialdehyde activity, glutathione levels,
myeloperoxidase activity, TNF-α, and NF-κB binding activity and its inhibitory protein IκBα
were studied in the pancreas. Furthermore, we measured plasma lipase and amylase and …
induced pancreatitis in NF-κB knockout (KO) mice. NF-κB KO mice and normal control
littermate wild-type (WT) mice were given four hyperstimulating doses of cerulein every hour
to elicit secreatagogue-induced pancreatitis. Malonildialdehyde activity, glutathione levels,
myeloperoxidase activity, TNF-α, and NF-κB binding activity and its inhibitory protein IκBα
were studied in the pancreas. Furthermore, we measured plasma lipase and amylase and …
