Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription …
K De Bosscher, WV Berghe, G Haegeman - Journal of neuroimmunology, 2000 - Elsevier
Glucocorticoids are the most widely used anti-inflammatory and immunomodulatory agents,
whose mechanism of action is based mainly on interference with the activity of transcription
factors, such as nuclear factor κB (NF-κB) and activator protein-1 (AP-1). The precise
molecular mechanisms of gene repression by glucocorticoids are a controversial matter, due
to the existence of many conflicting hypotheses. We discuss the three main paradigms
reported in the literature, namely the inhibitor κB-α (IκB-α) upregulatory model, the protein …
whose mechanism of action is based mainly on interference with the activity of transcription
factors, such as nuclear factor κB (NF-κB) and activator protein-1 (AP-1). The precise
molecular mechanisms of gene repression by glucocorticoids are a controversial matter, due
to the existence of many conflicting hypotheses. We discuss the three main paradigms
reported in the literature, namely the inhibitor κB-α (IκB-α) upregulatory model, the protein …