Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring

CS Fox, H Parise, RB D'Agostino Sr, DM Lloyd-Jones… - Jama, 2004 - jamanetwork.com
ContextAtrial fibrillation (AF) is the most common cardiac dysrhythmia in the United States.
Whereas rare cases of familial AF have been reported, it is unknown if AF among unselected
individuals is a heritable condition. ObjectiveTo determine whether parental AF increases
the risk for the development of offspring AF. Design, Setting, and ParticipantsProspective
cohort study (1983-2002) within the Framingham Heart Study, a population-based
epidemiologic study. Participants were 2243 offspring (1165 women, 1078 men) at least 30 …