A simple model of the build-up of resistance to mixtures of anti-malarial drugs
CF Curtis, LN Otoo - Transactions of the Royal Society of Tropical Medicine …, 1986 - Elsevier
In an organism with a life-cycle modelled on that of Plasmodium two separate resistance
genes are assumed, each protecting against one of two unrelated drugs. The model was
used to compare the rates of build-up of resistance in a population where the two drugs are
used either as a mixture or in sequence. The model suggests that the use of a mixture would
be advantageous if:(i) both resistances are initially rare;(ii) there is recombination between
the genes;(iii) a large proportion of the parasite population is unexposed to the drugs.
genes are assumed, each protecting against one of two unrelated drugs. The model was
used to compare the rates of build-up of resistance in a population where the two drugs are
used either as a mixture or in sequence. The model suggests that the use of a mixture would
be advantageous if:(i) both resistances are initially rare;(ii) there is recombination between
the genes;(iii) a large proportion of the parasite population is unexposed to the drugs.