The combined effect of inhibiting both ACAT and HMG-CoA reductase may directly induce atherosclerotic lesion regression
TMA Bocan, BR Krause, WS Rosebury, X Lu, C Dagle… - Atherosclerosis, 2001 - Elsevier
We hypothesized that coadministration of avasimibe and simvastatin would limit size,
composition and extent of atherosclerotic lesions and potentially promote lesion regression,
since bioavailable ACAT inhibitors decrease monocyte-macrophage enrichment and HMG-
CoA reductase inhibitors limit smooth muscle cell migration and proliferation. Male New
Zealand white rabbits were sequentially fed a 0.5% cholesterol, 3% peanut oil, 3% coconut
oil diet for 9 weeks and a chow-fat diet for 6 weeks prior to drug administration. A time zero …
composition and extent of atherosclerotic lesions and potentially promote lesion regression,
since bioavailable ACAT inhibitors decrease monocyte-macrophage enrichment and HMG-
CoA reductase inhibitors limit smooth muscle cell migration and proliferation. Male New
Zealand white rabbits were sequentially fed a 0.5% cholesterol, 3% peanut oil, 3% coconut
oil diet for 9 weeks and a chow-fat diet for 6 weeks prior to drug administration. A time zero …
