Prototypic disorders of gastrointestinal mucosal immune function: Celiac disease and Crohn's disease

SP James - Journal of allergy and clinical immunology, 2005 - Elsevier
Celiac disease is a disorder of the small intestine characterized by chronic inflammation of
the mucosa and protean clinical manifestations caused by loss of tolerance to dietary
antigens. Two strongly associated cofactors have been identified: the presence of HLA-DQ2
or HLA-DQ8 in the host and specific antigenic peptides in the diet that are present in wheat,
rye, and barley. Most patients have complete remission after dietary elimination of these
foods. Crohn's disease is characterized by chronic, relapsing, recurrent, focal, transmural …